منابع مشابه
Discordant cardiac xenotransplantation: broadening the horizons.
a Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany b Department of Cardiovascular Surgery, Ludwig-Maximilians University, Munich, Germany c Revivicor, Blacksburg, VA, USA d Living Cell Technologies, Auckland, New Zealand e Chair of Livestock Biotechnology, Weihenstephan, Technical University, Munich, Germany f Department of Anaesthesiology and Intensi...
متن کاملCardiac xenotransplantation: clinical experience and future direction.
The shortage of human organs has focused research on finding an animal source of replacement organs. The immunological barriers to xenotransplantation are now more clearly defined, allowing retrospective interpretation of past clinical experience in humans. Due to physiological compatibilities as well as ethical and infectious considerations, pigs have now emerged as the most likely source of f...
متن کاملEffect of miR-146a and miR-155 on cardiac xenotransplantation
The aim of the present study was to investigate the expression levels of miR-146a and miR-155 in a cardiac xenograft model treated with the immunosuppressant FK506, and to construct lentiviral vectors to further study the roles of miR-146a and miR-155 in cardiac xenotransplantation. Expression levels of miR-146a and miR-155 were examined by quantitative polymerase chain reaction analysis and pr...
متن کاملImmunosuppression and xenotransplantation of cells for cardiac repair.
The death of highly vulnerable cardiomyocytes during ischemia leads to cardiac dysfunction, including heart failure. Due to limited proliferation of adult mammalian cardiomyocytes, the dead myocardium is replaced by noncontractile fibrotic tissue. Introducing exogenous cells to participate in the regeneration of infarcted myocardium has thus been proposed as a novel therapeutic approach. In vie...
متن کاملFirst experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation.
BACKGROUND Heterotopic thoracic heart transplantation may be an alternative to the established heterotopic abdominal or orthotopic cardiac xenotransplantation model as it combines the safety of heterotopic transplantation with the benefit of a working heart model. METHODS In a first series of two animals, we tested the surgical feasibility of this procedure with non-transgenic pig hearts tran...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2012
ISSN: 1087-2418
DOI: 10.1097/mot.0b013e3283509120